Cytogenetic and molecular studies of male germ-cell tumors

摘要: Summary Although the biological significance of GCTs to study malignancy and differentiation has been well recognized for some time, detailed genetic analysis based on fresh tumor biopsies not initiated until recently. The first stage such studies, as with other, more extensively investigated systems, cytogenetic analysis. To date, data 225 tumors are available which, although small in number, have already yielded valueble insights into biology these a clinically useful marker. Thus, initial correlations between chromosome change histology recorded, gene amplification associated malignant progression identified, basis teratomatous lesions clarified, sites candidate suppressor genes unique this system identified. usefulness i(12p) diagnostic marker, especially uncertain histologies established. Because clinical molecularly methods its detection, without need formal analysis, developed. Cytogenetic larger prospectively ascertained series than performed so far large numbers utilizing molecular techniques can be expected yield significant behavior tumors.