Integrated sample collection and handling for drug discovery bioanalysis
作者： Nanyan Zhang , Karen Rogers , Karen Gajda , John R Kagel , David T Rossi
DOI: 10.1016/S0731-7085(00)00336-8
关键词:
摘要: An integrated sample handling process for drug discovery bioanalysis is described. The streamlining of study design, collection and automatic bioanalytical processing demonstrated. Specific details the entire procedure regarding time saved, ease automation integration are defined. Details involved a map, formatting volume, dilution schemes high concentration samples, choice biological fluid evaluating capabilities two liquid-handling workstations. Numerous comparisons were conducted between new approaches conventional approaches. precision accuracy obtained from comparable to those approach, as pharmacokinetic profiles parameters. This sampling greatly improved efficiency bioanalysis. pre-clinical protocol processes was also achieved.
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sci-hub.se 参考文章(12)
José M. Villalgordo, Daniel Obrecht, Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries ,(1998)
Judd Berman, Kathy Halm, Kim Adkison, Joel Shaffer, Simultaneous Pharmacokinetic Screening of a Mixture of Compounds in the Dog Using API LC/MS/MS Analysis for Increased Throughput Journal of Medicinal Chemistry. ,vol. 40, pp. 827- 829 ,(1997) , 10.1021/JM960702S
Tresavon D Parker, Narayanan Surendran, Barbra H Stewart, David T Rossi, Automated sample preparation for drugs in plasma using a solid-phase extraction workstation Journal of Pharmaceutical and Biomedical Analysis. ,vol. 17, pp. 851- 861 ,(1998) , 10.1016/S0731-7085(97)00278-1
Francis Beaudry, J. C. Yves Le Blanc, Michel Coutu, Nigel K. Brown, In vivo pharmacokinetic screening in cassette dosing experiments: the use of on-line prospekt® liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery Rapid Communications in Mass Spectrometry. ,vol. 12, pp. 1216- 1222 ,(1998) , 10.1002/(SICI)1097-0231(19980915)12:17<1216::AID-RCM304>3.0.CO;2-O
Timothy V. Olah, Debra A. McLoughlin, John D. Gilbert, The Simultaneous Determination of Mixtures of Drug Candidates by Liquid Chromatography/Atmospheric Pressure Chemical Ionization Mass Spectrometry as anIn Vivo Drug Screening Procedure Rapid Communications in Mass Spectrometry. ,vol. 11, pp. 17- 23 ,(1997) , 10.1002/(SICI)1097-0231(19970115)11:1<17::AID-RCM812>3.0.CO;2-N
Mark C. Bentley, Mohammed Abrar, Mark Kelk, Jeremy Cook, Keith Phillips, Validation of an assay for the determination of cotinine and 3-hydroxycotinine in human saliva using automated solid-phase extraction and liquid chromatography with tandem mass spectrometric detection Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 723, pp. 185- 194 ,(1999) , 10.1016/S0378-4347(98)00494-0
N.Helen Huang, John R Kagel, David T Rossi, Automated solid-phase extraction workstations combined with quantitative bioanalytical LC/MS Journal of Pharmaceutical and Biomedical Analysis. ,vol. 19, pp. 613- 620 ,(1999) , 10.1016/S0731-7085(98)00289-1
Heidi Simpson, Antoine Berthemy, Deborah Buhrman, Regina Burton, John Newton, Michael Kealy, David Wells, Danlin Wu, High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation Rapid Communications in Mass Spectrometry. ,vol. 12, pp. 75- 82 ,(1998) , 10.1002/(SICI)1097-0231(19980131)12:2<75::AID-RCM112>3.0.CO;2-C
Nanyan Zhang, Keith L Hoffman, Wenlin Li, David T Rossi, Semi-automated 96-well liquid-liquid extraction for quantitation of drugs in biological fluids. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 22, pp. 131- 138 ,(2000) , 10.1016/S0731-7085(99)00247-2
Joel E. Shaffer, Kimberly K. Adkison, Kathy Halm, Kevin Hedeen, Judd Berman, Use of "N-in-One" dosing to create an in vivo pharmacokinetics database for use in developing structure-pharmacokinetic relationships. Journal of Pharmaceutical Sciences. ,vol. 88, pp. 313- 318 ,(1999) , 10.1021/JS980292Q