Benzothiophene-based selective estrogen receptor downregulators

作者: Jiong Zhao , Debra A. Tonetti , Gregory R. Thatcher , Rui Xiong

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摘要: This invention is benzothiophene-based estrogen receptor downregulators and their compositions uses to treat estrogen-related medical disorders.

参考文章(132)
Nicholas D. Smith, Celine Bonnefous, Jackaline D. Julien, Steven P. Govek, Mehmet Kahraman, Polycyclic estrogen receptor modulators and uses thereof ,(2014)
Meghan Davis, Young Jun Kim, Juan Fu, Drew M. Pardoll, Charles George Drake, Immunogenic compositions and methods for treating neoplasia ,(2011)
Simon Nicholas Jenkins, Barry Samuel Komm, Methods of inhibiting uterotrophic effects of estrogenic agents ,(2001)
Steven Jay Adelman, Thomas Michaell Argentieri, Use of substituted indole compounds for increasing nitric oxide synthase activity ,(2001)
David C. Myles, Leslie Hodges Gallagher, Peter J. Kushner, Cyrus L. Harmon, Combinations of benzopyran compounds, compositions and uses thereof ,(2014)
Jeffrey H. Hager, Nicholas D. Smith, Edna Chow Maneval, Steven P. Govek, Mehmet Kahraman, Azetidine estrogen receptor modulators and uses thereof ,(2014)
Hazel M. Weir, Robert H. Bradbury, Mandy Lawson, Alfred A. Rabow, David Buttar, Rowena J. Callis, Jon O. Curwen, Camila de Almeida, Peter Ballard, Michael Hulse, Craig S. Donald, Lyman J.L. Feron, Galith Karoutchi, Philip MacFaul, Thomas Moss, Richard A. Norman, Stuart E. Pearson, Michael Tonge, Gareth Davies, Graeme E. Walker, Zena Wilson, Rachel Rowlinson, Steve Powell, Claire Sadler, Graham Richmond, Brendon Ladd, Ermira Pazolli, Anne Marie Mazzola, Celina D'Cruz, Chris De Savi, AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models Cancer Research. ,vol. 76, pp. 3307- 3318 ,(2016) , 10.1158/0008-5472.CAN-15-2357
Birong Zhang, Nicholas Charles Ray, Daniel Fred Ortwine, Jun Liang, Simon Charles Goodacre, Jason Zbieg, Sharada Labadie, Xiaojing Wang, TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF ,(2015)