Identification and Validation of Lymphovascular Invasion as a Prognostic and Staging Factor in Node-Negative Esophageal Squamous Cell Carcinoma

摘要: Abstract Introduction Lymphovascular invasion (LVI) is a histopathological feature that associated with an increased risk for micrometastasis. The aim of this study was to determine the prognostic and staging value LVI among patients esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy. Methods A prospective database ESCC used retrospectively analyze 666 cases identify relationship between survival, evaluate predictive accuracy prognosis after combining tumor, node, metastasis (TNM) system. Pathological slides were reassessed by gastrointestinal pathologists according to strict criteria; 1000-bootstrap resampling internal validation, 222 from independent multicenter external validation. Results present in 33.8% patients, proportion advancing T N classification. predictor unfavorable disease-specific survival (DSS) (hazard ratio = 1.59, 95% confidence interval: 1.30–1.94) disease-free (DFS) 1.62, 1.32–1.98) Among node-negative classification two predictors DSS DFS ( p > 0.05). In contrast, not or node-positive patients. Conclusions significance of LVI existed only ESCC, and the combination TNM system enhanced the predictive prognosis. After confirmation, might be considered upstaging pathological staging.