Minidose gonadotropin-releasing hormone agonist is the treatment of choice in poor responders with high follicle-stimulating hormone levels
作者： Dov Feldberg , Jacob Farhi , Jacob Ashkenazi , Dov Dicker , Joseph Shalev
DOI: 10.1016/S0015-0282(16)56889-7
关键词:
摘要: Objective To investigate the effectiveness of minidose GnRH agonist (GnRH-a)+hMG in poor responders with elevated basal level FSH. Design Restrospective analysis IVF cycles. Setting Unit, Golda Medical Center, Petah Tikva, Israel. Patients One hundred six patients who were defined as on two previous attempts. Three treatment protocols midluteal Decapeptyl (D-Trp 6 ) compared: [1] a single-dose 3.75mg; [2] 0.5mg daily until menstruation, followed by 0.1mg daily; and [3] 0.05mg daily. Main Outcome Measures Comparisons made among three regarding FSH levels, number oocytes retrieved fertilized, days stimulation, follicular phase, P pregnancy miscarriage rates. Results Treatment GnRH-a resulted higher E 2 levels lower day hCG cancellation Furthermore, recovered fertilized embryos transferred recorded. The trend indicated improved implantation rates rate. Conclusion Minidose is better choice than regular strategies poor-responder undergoing treatment.
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sci-hub.se 参考文章(14)
Z. Ben-Rafael, Y. Menashe, R. Mimon, S. Lipitz, D. Bider, M. Zolti, U. Dan, C. Pariente, J. Shalev, J. Dor, D. Levran, S. Mashiach, Limitations in the Use of Combined Gonadotropin Releasing Hormone Analog and Human Menopausal Gonadotropin for In Vitro Fertilization Springer, Boston, MA. pp. 17- 29 ,(1990) , 10.1007/978-1-4613-0645-0_2
Katharine L. Sheehan, Robert F. Gasper, Samuel S.C. Yen, Induction of luteolysis by luteinizing hormone-releasing factor (LRF) agonist: sensitivity, reproducibility, and reversibility* Fertility and Sterility. ,vol. 37, pp. 209- 212 ,(1982) , 10.1016/S0015-0282(16)46041-3
Hung-Ching Liu, Ying-Ming Lai, Owen Davis, Alan S. Berkeley, Margaret Graf, Jimmy Grifo, Jacques Cohen, Zev Rosenwaks, Improved pregnancy outcome with gonadotropin releasing hormone agonist (GnRH-a) stimulation is due to the improvement in oocyte quantity rather than quality. Journal of Assisted Reproduction and Genetics. ,vol. 9, pp. 338- 344 ,(1992) , 10.1007/BF01203956
Rachel Popkin, T.A. Bramley, Aileen Currie, R.W. Shaw, D.T. Baird, H.M. Fraser, Specific binding of luteinizing hormone releasing hormone to human luteal tissue Biochemical and Biophysical Research Communications. ,vol. 114, pp. 750- 756 ,(1983) , 10.1016/0006-291X(83)90844-6
Daniel Navot, Zev Rosenwaks, Freedolph Anderson, Gary D. Hodgen, Gonadotropin-releasing hormone agonist-induced ovarian hyperstimulation : low-dose side effects in women and monkeys Fertility and Sterility. ,vol. 55, pp. 1069- 1075 ,(1991) , 10.1016/S0015-0282(16)54354-4
Patrick Fénichel, Martine Grimaldi, Jean-François Olivero, Michèle Donzeau, Jean-Yves Gillet, Michel Harter, Predictive value of hormonal profiles before stimulation for in vitro fertilization. Fertility and Sterility. ,vol. 51, pp. 845- 849 ,(1989) , 10.1016/S0015-0282(16)60677-5
Avner Hershlag, Maria C. Asis, Michael P. Diamond, Alan H. DeCherney, Gad Lavy, The predictive value and the management of cycles with low initial estradiol levels. Fertility and Sterility. ,vol. 53, pp. 1064- 1067 ,(1990) , 10.1016/S0015-0282(16)53586-9
Muttakrishna Sathanandan, Graham M. Warnes, Christine A. Kirby, Oswald M. Petrucco, Colin D. Matthews, Adjuvant leuprolide in normal, abnormal, and poor responders to controlled ovarian hyperstimulation for in vitro fertilization/gamete intrafallopian transfer Fertility and Sterility. ,vol. 51, pp. 998- 1006 ,(1989) , 10.1016/S0015-0282(16)60733-1
Paulo Serafini, Bronte Stone, John Kerin, Joel Batzofin, Patrick Quinn, Richard P. Marrs, An alternate approach to controlled ovarian hyperstimulation in “poor responders”: pretreatment with a gonadotropin-releasing hormone analog**Presented at the forty-third annual meeting of The American Fertility Society, September 28 to 30, 1987, Reno, Nevada. Fertility and Sterility. ,vol. 49, pp. 90- 95 ,(1988) , 10.1016/S0015-0282(16)59655-1
Kathleen Droesch, Suheil J. Muasher, Robert G. Brzyski, Georgeanna S. Jones, Simonetta Simonetti, Hung-Ching Liu, Zev Rosenwaks, Value of suppression with a gonadotropin-releasing hormone agonist prior to gonadotropin stimulation for in vitro fertilization Fertility and Sterility. ,vol. 51, pp. 292- 297 ,(1989) , 10.1016/S0015-0282(16)60493-4