Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field.

摘要: Magnetic nanoparticles (MNPs) functionalized with targeting moieties can recognize specific cell components and induce mechanical actuation under magnetic field. Their size is adequate for reaching tumors cancer cells. However, due to the nanometric size, force generated by MNPs smaller than required largely disrupting key of Here, we show assembly process inside cells, form elongated aggregates produce elevated forces. We synthesized iron oxide doped zinc, obtain high magnetization, epidermal growth factor (EGF) peptide Under a low frequency rotating field at 15 Hz 40 mT, internalized EGF-MNPs formed hundreds pN dramatically damage plasma lysosomal membranes. The physical disruption, including leakage hydrolases into cytosol, led programmed death necrosis. Our work provides novel strategy designing nanomedicines destruction