Persistence of epidermal growth factor receptor and interleukin 10 in blood of colorectal cancer patients after surgery identifies patients with high risk to relapse.

摘要: Purpose: Despite the great number of studies performed to detect circulatingmarkers disease progression in colorectal cancer, few have shown a clinical use; among those, epidermal growth factor receptor (EGFR) and, more recently, interleukin (IL)-10. In this article, we sought investigate how primary surgery could affect expression levels EGFR, IL-6, and IL-10 blood from cancer patients. Experimental Design: We investigated by reverse transcriptase-PCR assay at mRNA level samples taken 56 Each gene was evaluated 1 day before 20 days after surgery. Persistence each then correlated relapse free time follow-up 3 years. Results: surgery, were found expressed 62, 100, 100% patients, respectively. EGFR expression, but not IL-6 IL-10, correlates with stage disease. group 41 patients who underwent studies, persistently high 67%; 94% them had relapse. also identifies relapses 89% cases. persistence significantly correlate Conclusions: both propensity These findings may suggest use preoperative EGFR/IL-10 prediction tumor recurrence.