Selection of and evasion from cytotoxic T cell responses in the central nervous system.

摘要: Publisher Summary Cytotoxic CD8 T lymphocytes (CTLs) are critical for the clearance of noncytopathic viruses from infected cells. This chapter discusses one mechanism used by to persist—namely, selection a variant virus in which changes sequence CTL epitope abrogate recognition. The unique features cytotoxic cell function central nervous system (CNS) discussed. role escape mutants viral evasion immune and subsequent disease progression non-CNS infections summarized. response CNS is similar extraneural tissue, but several aspects activation response, cellular trafficking, antigen presentation CNS. Although has classically been considered site privilege, surveillance normal circulating, activated occurs, with limited number being present at any given time. In mice mouse hepatitis some humans persistently human immunodeficiency type1, B or C virus, play an important amplification progression.