Protein aggregation - Mechanisms, detection, and control.

作者: Wei Wang , Christopher J. Roberts

DOI: 10.1016/J.IJPHARM.2018.08.043

关键词:

摘要: Protein aggregation has been recognized as one of the major challenges in the development and commercialization of successful protein-based drug products because of …

参考文章(492)
Marcus T. Cicerone, Michael J. Pikal, Ken K. Qian, Stabilization of proteins in solid form. Advanced Drug Delivery Reviews. ,vol. 93, pp. 14- 24 ,(2015) , 10.1016/J.ADDR.2015.05.006
Satish K. Singh, Donna L. Luisi, Roger H. Pak, Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability Pharmaceutical Research. ,vol. 32, pp. 3541- 3571 ,(2015) , 10.1007/S11095-015-1704-4
Roy J. B. M. Delahaije, Peter A. Wierenga, Marco L. F. Giuseppin, Harry Gruppen, Comparison of heat-induced aggregation of globular proteins. Journal of Agricultural and Food Chemistry. ,vol. 63, pp. 5257- 5265 ,(2015) , 10.1021/ACS.JAFC.5B00927
Alexis Oliva, Matías Llabrés, José B Fariña, None, Fitting bevacizumab aggregation kinetic data with the Finke–Watzky two-step model: Effect of thermal and mechanical stress European Journal of Pharmaceutical Sciences. ,vol. 77, pp. 170- 179 ,(2015) , 10.1016/J.EJPS.2015.06.011
Vera A. Borzova, Kira A. Markossian, Dmitriy A. Kara, Boris Kurganov, Kinetic regime of dithiothreitol-induced aggregation of bovine serum albumin. International Journal of Biological Macromolecules. ,vol. 80, pp. 130- 138 ,(2015) , 10.1016/J.IJBIOMAC.2015.06.040
Gregory V. Barnett, Wei Qi, Samiul Amin, E. Neil Lewis, Christopher J. Roberts, Aggregate structure, morphology and the effect of aggregation mechanisms on viscosity at elevated protein concentrations Biophysical Chemistry. ,vol. 207, pp. 21- 29 ,(2015) , 10.1016/J.BPC.2015.07.002
Arne Schön, Benjamin R. Clarkson, Rogelio Siles, Patrick Ross, Richard K. Brown, Ernesto Freire, Denatured state aggregation parameters derived from concentration dependence of protein stability. Analytical Biochemistry. ,vol. 488, pp. 45- 50 ,(2015) , 10.1016/J.AB.2015.07.013
Luis M. Blancas-Mejía, Timothy J. Horn, Marta Marin-Argany, Matthew Auton, Alexander Tischer, Marina Ramirez-Alvarado, Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding. Biophysical Chemistry. ,vol. 207, pp. 13- 20 ,(2015) , 10.1016/J.BPC.2015.07.005
A. Quigley, D.R. Williams, The second virial coefficient as a predictor of protein aggregation propensity: A self-interaction chromatography study. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 96, pp. 282- 290 ,(2015) , 10.1016/J.EJPB.2015.07.025
Lara Galm, Josefine Morgenstern, Jürgen Hubbuch, Manipulation of lysozyme phase behavior by additives as function of conformational stability International Journal of Pharmaceutics. ,vol. 494, pp. 370- 380 ,(2015) , 10.1016/J.IJPHARM.2015.08.045