Disorders of growth hormone and corticotropin regulation in patients with empty sella

摘要: ✓ Endocrine functions in seven cases of primary empty sella were studied. No clinical features endocrine disturbances apparent. Urinary excretion gonadotropins, and thyroid adrenal normal. Plasma human growth hormone (HGH) concentration was also normal but did not increase after insulin-induced hypoglycemia four patients, arginine one, a glucose load six. 17-hydroxycorticosteroids (17-OHCS) increased normally all patients metyrapone administration, while plasma 17-OHCS three subjects or one lysine-vasopressin. Two showed exaggerated responses to These results indicate an impairment the hypothalamic HGH corticotropin regulation with sella. Since chromophobe adenomas comparable changes seen, differential diagnosis between adenoma is impossible on basis endocrino...