Separation of enatiomers of drugs by capillary electrophoresis III. β-cyclodextrin as chiral solvating agent
作者： B. Koppenhoefer , U. Epperlein , B. Christian , B. Lin , Y. Ji
DOI: 10.1016/0021-9673(95)01210-9
关键词:
摘要: Abstract Enantiomer separation by capillary zone electrophoresis was studied for a set of 34 chiral drugs. Keeping the concentration β-cyclodextrin as solvating agent constant possible led to seven enetiomeeric pairs. Carvedilol, Tetryzoline, Tropicamide and Zopiclone gave baseline separtion, Chlorphenamine, Ketamine, Orciprenaline partial separation. Statistical analysis revealed that best factors were observed medium degree interaction with cyclodextrin. A theory explaining this effect provides helpful guideline further optimization.
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