Sex and Mitonuclear Adaptation in Experimental Caenorhabditis elegans Populations.

作者: Riana I. Wernick , Stephen F. Christy , Dana K. Howe , Jennifer A. Sullins , Joseph F. Ramirez

DOI: 10.1534/GENETICS.119.301935

关键词:

摘要: To reveal phenotypic and functional genomic patterns of mitonuclear adaptation, a laboratory adaptation study with Caenorhabditis elegans nematodes was conducted in which independently evolving lines were initiated from low-fitness mitochondrial electron transport chain (ETC) mutant, gas-1 Following 60 generations evolution large population sizes competition for food resources, two distinct classes representing different degrees adaptive response emerged: class that exhibited minimal or no improvement compared to the mutant ancestor, high-fitness containing partial recovery wild-type fitness. Many achieved higher reproductive competitive fitness levels also noted evolve high frequencies males during experiment, consistent these having been facilitated by outcrossing. Whole-genome sequencing analysis revealed an enrichment mutations loci occur gas-1-centric region C. interactome could be classified into small number categories. A highly nonrandom pattern DNA mutation observed within lines, parallel fixations nonsynonymous base substitutions genes encoding NADH dehydrogenase subunits I VI. These gene products reside ETC complex alongside nuclear-encoded GAS-1 protein, suggesting rapid select driven fixation compensatory mutations.

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