The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21.

摘要: B7 is an activation antigen expressed on activated B cells and gamma- interferon-stimulated monocytes. The the natural ligand for CD28 T cells. After engagement of T-cell receptor with in association major histocompatibility complex class II, a second signal mediated through binding to greatly upregulates production multiple lymphokines. We have now mapped gene human chromosome 3 using technique polymerase chain reaction panel hamster x somatic cell hybrid DNAs. further localized 3q13.3–3q21 situ hybridization metaphase chromosomes. Trisomy recurrent change seen various lymphomas lymphoproliferative diseases, particularly diffuse, mixed, small, large lymphomas, lymphotropic virus type I-induced adult leukemia, angioimmunoblastic lymphadenopathy. A number chromosomal defects involving 3q21 been described acute myeloid leukemia also myelodysplastic myeloproliferative syndromes. mapping may permit insight into disease states associated aberrant lymphocyte lymphokine synthesis.