Effects of Deep Brain Stimulation of the Subthalamic Nucleus Settings on Voice Quality, Intensity, and Prosody in Parkinson's Disease: Preliminary Evidence for Speech Optimization.

摘要: Objective: To systematically evaluate how different deep brain stimulation of the subthalamic nucleus (STN-DBS) amplitude, frequency, and pulse-width electrical parameter settings impact speech intensity, voice quality, prosody in Parkinson’s disease (PD). Methods: Ten individuals with PD receiving bilateral STN-DBS treatments were seen for three baseline five treatment visits. The visits involved an examination standard clinical as well manipulation combinations frequency (low, mid, high), pulse width voltage high) stimulation. Measures jitter, shimmer, harmonics–noise ratio, semitone deviation, listener ratings quality obtained each manipulation. Results: lower width, higher associated improved outcomes compared to current settings. In addition, decreased total energy delivered STN appears be improvements. Conclusions: This study provides preliminary evidence that may optimized Parkinson-related problems speech.