Oxidative Insult After Ischemia/Reperfusion in Older Adults

摘要: Aging is associated with significant impairment in tolerance to acute stressors such as ischemia/reperfusion and this appears contribute the increased morbidity mortality of older adults compared young clinical conditions ischemia/reperfusion. These include ischemic heart disease, stroke, a variety surgeries. Ischemia leads transition from aerobic anaerobic metabolism subsequent depletion ATP, accumulation lactate, acidosis, loss intracellular ion homeostasis. Reperfusion results oxidative stress calcium overload which together stimulate pathways necrosis apoptosis. adverse events are exaggerated individuals. In particular, plays central role age-related increase vulnerability We outline useful forearm method assess have shown that several interventions can markedly improve resistance