6‐O‐(3″, 4″‐di‐O‐trans‐cinnamoyl)‐α‐l‐rhamnopyranosylcatalpol and verbascoside: Cytotoxicity, cell cycle kinetics, apoptosis, and ROS production evaluation in tumor cells
作者： Alexandru Vasincu , Christiana M. Neophytou , Simon Vlad Luca , Krystyna Skalicka‐Woźniak , Anca Miron
DOI: 10.1002/JBT.22443
关键词:
摘要: The aim of this study was to evaluate the impact that 6-O-(3″, 4″-di-O-trans-cinnamoyl)-α- l-rhamnopyranosylcatalpol (Dicinn) and verbascoside (Verb), two compounds simultaneously reported in Verbascum ovalifolium, have on tumor cell viability, apoptosis, cycle kinetics, intracellular reactive oxygen species (ROS) level. At 100 µg/mL 48 hours incubation time, Dicinn Verb produced good cytotoxic effects A549, HT-29, MCF-7 cells. induced cell-cycle arrest at G0 /G1 phase whereas increased population subG1 cells apoptosis rates. Furthermore, exhibited time-dependent ROS generating (1-24 hours). Importantly, no were nontumor MCF-10A by up 100 µg/mL. Overall, more potent, which can be correlated with its structural features, such as presence phenolic hydroxyl groups.
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