Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages
作者： Kristina Zec , Julia Volke , Nirojah Vijitha , Stephanie Thiebes , Matthias Gunzer
关键词:
摘要: The antibacterial defense against infections depends on the cooperation between distinct phagocytes of innate immune system, namely macrophages and neutrophils. However, mechanisms driving this are incompletely understood. In study we describe crosstalk Ly6C+ Ly6C− macrophage-subtypes neutrophils in context urinary tract infection (UTI) with uropathogenic E. coli (UPEC). acted as tissue resident sentinels attracted circulating by chemokines. produced tumor necrosis factor (TNF) that licensed to release preformed CXCL2, which turn caused matrix metalloproteinases (MMP-9) secretion enable transepithelial migration.
mdpi.com
core.ac.uk
immunodynamics.de 参考文章(38)
Jeffrey E. Gershenwald, Reuven Reich, Menashe Bar-Eli, Suyun Huang, Mario Luca, Rakesh K. Singh, Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis American Journal of Pathology. ,vol. 151, pp. 1105- 1113 ,(1997)
Mathieu-Benoît Voisin, Doris Pröbstl, Sussan Nourshargh, Venular Basement Membranes Ubiquitously Express Matrix Protein Low-Expression Regions The American Journal of Pathology. ,vol. 176, pp. 482- 495 ,(2010) , 10.2353/AJPATH.2010.090510
Daniel R. Engel, Juliane Maurer, André P. Tittel, Christina Weisheit, Taner Cavlar, Beatrix Schumak, Andreas Limmer, Nico van Rooijen, Christian Trautwein, Frank Tacke, Christian Kurts, CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection. Journal of Immunology. ,vol. 181, pp. 5579- 5586 ,(2008) , 10.4049/JIMMUNOL.181.8.5579
Nico van Rooijen, Cindy A. Salkowski, Stefanie N. Vogel, Jennifer Major, Karen M. Kopydlowski, M. Joshua Cody, Thomas A. Hamilton, Regulation of Macrophage Chemokine Expression by Lipopolysaccharide In Vitro and In Vivo Journal of Immunology. ,vol. 163, pp. 1537- 1544 ,(1999)
Marie Benoit, Benoît Desnues, Jean-Louis Mege, Macrophage Polarization in Bacterial Infections Journal of Immunology. ,vol. 181, pp. 3733- 3739 ,(2008) , 10.4049/JIMMUNOL.181.6.3733
Valerie S. LeBleu, Brian MacDonald, Raghu Kalluri, Structure and function of basement membranes Experimental Biology and Medicine. ,vol. 232, pp. 1121- 1129 ,(2007) , 10.3181/0703-MR-72
Christian Kurts, Ulf Panzer, Hans-Joachim Anders, Andrew J. Rees, The immune system and kidney disease: basic concepts and clinical implications Nature Reviews Immunology. ,vol. 13, pp. 738- 753 ,(2013) , 10.1038/NRI3523
Anja Hasenberg, Mike Hasenberg, Linda Männ, Franziska Neumann, Lars Borkenstein, Manuel Stecher, Andreas Kraus, Daniel R Engel, Anika Klingberg, Pegah Seddigh, Zeinab Abdullah, Sabrina Klebow, Swen Engelmann, Annegret Reinhold, Sven Brandau, Michaela Seeling, Ari Waisman, Burkhart Schraven, Joachim R Göthert, Falk Nimmerjahn, Matthias Gunzer, Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes. Nature Methods. ,vol. 12, pp. 445- 452 ,(2015) , 10.1038/NMETH.3322
Klaus Pfeffer, Toshifumi Matsuyama, Thomas M. Kündig, Andrew Wakeham, Kenji Kishihara, Arda Shahinian, Katja Wiegmann, Pamela S. Ohashi, Martin Krönke, Tak W. Mak, Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell. ,vol. 73, pp. 457- 467 ,(1993) , 10.1016/0092-8674(93)90134-C
Christian Schulz, Elisa Gomez Perdiguero, Laurent Chorro, Heather Szabo-Rogers, Nicolas Cagnard, Katrin Kierdorf, Marco Prinz, Bishan Wu, Sten Eirik W. Jacobsen, Jeffrey W. Pollard, Jon Frampton, Karen J. Liu, Frederic Geissmann, A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells Science. ,vol. 336, pp. 86- 90 ,(2012) , 10.1126/SCIENCE.1219179