Positron emission tomography of sodium glucose cotransport activity in high grade astrocytomas.

摘要: A novel glucose transporter, the sodium cotransporter 2 (SGLT2), has been demonstrated to contribute demand for by pancreatic and prostate tumors, its functional activity imaged using a SGLT specific PET imaging probe, α-methyl-4-[F-18]fluoro-4-deoxy-D-glucopyaranoside (Me-4FDG). In this study, Me-4FDG was extended evaluate patients with high-grade astrocytic tumors. scans were performed in four diagnosed WHO Grade III or IV astrocytomas control subjects, compared 2-deoxy-2-[F-18]fluoro-D-glucose (2-FDG) magnetic resonance (MRI) of same subjects. Immunocytochemistry carried out on determine cellular location proteins within retention pronounced dramatic contrast lack uptake into normal brain, resulting high signal-to-noise ratio. Macroscopically, distribution tumors overlapped that 2-FDG tumor definition contrast-enhanced MRI images. Microscopically, SGLT2 protein found be expressed neoplastic glioblastoma cells endothelial proliferating microvasculature. This preliminary study shows is highly sensitive probe visualization PET. The 2-FDG, but absence background brain resulted superior sensitivity. Furthermore, presence astrocytoma microvasculature may offer therapy inhibitors already approved FDA treat type diabetes mellitus.