Rapid immunologic reconstitution following transplantation with mobilized peripheral blood stem cells as compared to bone marrow

摘要: A majority of patients with intermediate or high-grade non-Hodgkin's lymphoma (NHL) who are treated high-dose chemotherapy (HDT) and hematopoietic stem cell transplantation subsequently relapse. Until recently, was associated high morbidity mortality the focus on improving safety this procedure. However, use growth factors other supportive measures has successfully reduced treatment to less than 5%. Therefore, new strategies need be developed eliminate any occult tumor cells reinfused products remaining in patient. One approach is improve immune function by a more rapid reconstitution augmentation effector function. We report studies comparing recovery following HDT autologous peripheral (PSCT) as compared bone marrow (ABMT). These examined were PSCT (n = 56) ABMT 60). The had significantly faster circulating monocytes (CD14+ cells), natural killer ((NK) CD56+) cells, T helper (CD4+) TCR gamma/delta naive lymphocytes (CD45RA+). Following there increase frequency suppressor/effector (CD8+) B (CD19+) CD34+ polymorphonuclear leukocytes (PMN) memory (CD45RO+). CD4:CD8 CD45RA:CD45RO ratios consistently higher group suggesting an improved ratio effector/suppressor cells. differences cellular phenotype translated into (PHA mitogenesis) help (pokeweed mitogenesis). In addition, accelerated NK activity ABMT. rescued may contribute clinical outcome. Further, receiving responsive adjuvant immunotherapy transplantation.