Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease

作者: O Winqvist , J Gustafsson , F Rorsman , F A Karlsson , O Kämpe

DOI: 10.1172/JCI116843

关键词:

摘要: … The mitochondrial pellet was suspended in 10 mMTris-HCI, pH 7.0. … cytochrome P450 cholesterol side chain cleavage enzyme is not, however, present in all tissues that may be affected …

参考文章(32)
W. J. Irvine, A. G. Stewart, Laura Scarth, A clinical and immunological study of adrenocortical insufficiency (Addison's disease). Clinical and Experimental Immunology. ,vol. 2, pp. 31- 70 ,(1967)
Ingemar Björkhem, Jan Gustafsson, Mitochondrial w-Hydroxylation of Cholesterol Side Chain Journal of Biological Chemistry. ,vol. 249, pp. 2528- 2535 ,(1974) , 10.1016/S0021-9258(19)42762-2
M T Tusie-Luna, P Traktman, P C White, Determination of functional effects of mutations in the steroid 21-hydroxylase gene (CYP21) using recombinant vaccinia virus. Journal of Biological Chemistry. ,vol. 265, pp. 20916- 20922 ,(1990) , 10.1016/S0021-9258(17)45304-X
Timothy J. Triche, Timothy J. Triche, George P. Chrousos, George P. Chrousos, Adi F. Gazdar, Cedric H. Shackleton, Charles E. Myers, Renato V. La Rocca, Herbert K. Oie, T. R. Chen, C. A. Stein, Murray F. Brennan, Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis Cancer Research. ,vol. 50, pp. 5488- 5496 ,(1990)
J. Paul Banga, Alan M. McGregor, Enzymes as targets for autoantibodies in human autoimmune disease: relevance to pathogenesis? Autoimmunity. ,vol. 9, pp. 177- 182 ,(1991) , 10.3109/08916939109006755
R.M Blizzard, M.A Kyle, R.W Chandler, W Hung, ADRENAL ANTIBODIES IN ADDISON'S DISEASE The Lancet. ,vol. 280, pp. 901- 903 ,(1962) , 10.1016/S0140-6736(62)90681-5
K. Krohn, R. Uibo, E. Aavik, P. Peterson, K. Savilahti, R. Uibo, P. Peterson, Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase The Lancet. ,vol. 339, pp. 770- 773 ,(1992) , 10.1016/0140-6736(92)91894-E
PEKKA AHONEN, SAIJA KOSKIMIES, MARJA-LIISA LOKKI, ANJA TIILIKAINEN, JAAKKO PERHEENTUPA, The Expression of Autoimmune Polyglandular Disease Type I Appears Associated With Several HLA-A Antigens But Not With HLA-DR* The Journal of Clinical Endocrinology and Metabolism. ,vol. 66, pp. 1152- 1157 ,(1988) , 10.1210/JCEM-66-6-1152
K. Morohashi, Y. Fujii-Kuriyama, Y. Okada, K. Sogawa, T. Hirose, S. Inayama, T. Omura, Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 4647- 4651 ,(1984) , 10.1073/PNAS.81.15.4647