Relationships between lung adenocarcinoma and gender, age, smoking and occupational risk factors: A case–case study

摘要: Abstract Background The hypothesis that some risk factors for lung cancer may have more specific associations with particular histologic types remains controversial. aim of this study was to investigate possible between adenocarcinoma and gender, age, smoking characteristics selected occupational carcinogens in relation other types. Methods This included all histologically confirmed cases diagnosed consecutively two French University hospitals from 1997 2006. All medical data were obtained by face-to-face patient interviews. Occupational carcinogen exposures each assessed an industrial hygienist. Relationships analyzed case–case comparisons using unconditional logistic regressions (ULRs). Results A total 1493 subjects enrolled study, comprising 1303 men (87.3%), 67 nonsmokers (4.5%) 489 adenocarcinomas (32.7%). Using ULR, no observed gender or except a negative relationship duration ( p Conclusion demonstrated factors, such as certain but not important influence on the incidence ADC than As distribution reflect underlying biological mechanisms, these findings also suggest carcinogenesis pathways should be studied factors.