Clarithromycin and pulmonary infiltration with eosinophilia

摘要: Pulmonary diseases induced by drugs include bronchial asthma, pulmonary infiltration with eosinophilia, diffuse fibrosing alveolitis, vasculitis, and pleural diseases.1–4 Most such recede when the drug is withdrawn, although on rare occasions damage irreversible progressive.4 5 We describe a patient asthma referred to our respiratory clinic who twice developed fever eosinophilia after taking antibiotics. A 17 year old white man has had since childhood was in January 2002. The also reported sinusitis allergic rhinitis. Results of earlier prick tests radioallergosorbent were positive for wall pellitory ( Parietaria judaica ) grasses, resulted mild increase peripheral blood eosinophil counts (0.6-0.7 × 109/l (6-7%)). His general practitioner prescribed salbutamol as rescue treatment. did not report any allergy drugs. In December 2001 he (38°C), accompanied mucopurulent nasal secretion pain his forehead. X ray pictures paranasal sinuses showed maxillary right side hypertrophy turbinates. combined amoxicillin (875 mg) clavulanic acid (125 daily seven days, followed clarithromycin (500 further days. Figure 1 shows patient's course At end this treatment period dry cough dyspnoea. Chest x consolidations localised at apex. Fig Temporal relation between …