The direct thrombin inhibitor hirudin
作者： Theodore Warkentin , Andreas Greinacher
DOI: 10.1160/TH07-11-0693
关键词:
摘要: … the binding of thrombin to … thrombin, ie they are bivalent direct thrombin inhibitors. The arginine derivative argatroban binds competitively to only the active binding site pocket of thrombin…
thieme-connect.de 参考文章(87)
Fabrizio Mc, Use of ecarin clotting time (ECT) with lepirudin therapy in heparin-induced thrombocytopenia and cardiopulmonary bypass. The journal of extra-corporeal technology. ,vol. 33, pp. 117- 125 ,(2001)
Bernd Pötzsch, Katharina Madlener, Christoph Seelig, Christian F Riess, Andreas Greinacher, Gert Müller-Berghaus, Monitoring of r-hirudin anticoagulation during cardiopulmonary bypass--assessment of the whole blood ecarin clotting time. Thrombosis and Haemostasis. ,vol. 77, pp. 920- 925 ,(1997) , 10.1055/S-0038-1656078
Bernd Jaeger, Andreas Greinacher, Petra Eichler, Heinz-Juergen Friesen, Norbert Lubenow, Antihirudin antibodies in patients with heparin-induced thrombocytopenia treated with lepirudin: incidence, effects on aPTT, and clinical relevance Blood. ,vol. 96, pp. 2373- 2378 ,(2000) , 10.1182/BLOOD.V96.7.2373
Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients'data The Lancet. ,vol. 359, pp. 294- 302 ,(2002) , 10.1016/S0140-6736(02)07495-0
B Farner, P Eichler, H Kroll, A Greinacher, None, A comparison of danaparoid and lepirudin in heparin-induced thrombocytopenia Thrombosis and Haemostasis. ,vol. 85, pp. 950- 957 ,(2001) , 10.1055/S-0037-1615946
Volker Liebe, Renata Hudek, Dieter Heene, Guenter Huhle, Anti-r-hirudin antibodies reveal clinical relevance through direct functional inactivation of r-hirudin or prolongation of r-hirudin's plasma halflife. Thrombosis and Haemostasis. ,vol. 85, pp. 936- 938 ,(2001) , 10.1055/S-0037-1615773
Fritz Markwardt, Development of hirudin as an antithrombotic agent. Seminars in Thrombosis and Hemostasis. ,vol. 15, pp. 269- 282 ,(1989) , 10.1055/S-2007-1002719
E M Antman, Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial. Circulation. ,vol. 90, pp. 1624- 1630 ,(1994) , 10.1161/01.CIR.90.4.1624
A. J. Bircher, T. Harr, L. Hohenstein, D. A. Tsakiris, Hypersensitivity reactions to anticoagulant drugs: diagnosis and management options Allergy. ,vol. 61, pp. 1432- 1440 ,(2006) , 10.1111/J.1398-9995.2006.01227.X
Gerd Hafner, Markus Roser, Matthias Nauck, Methods for the monitoring of direct thrombin inhibitors. Seminars in Thrombosis and Hemostasis. ,vol. 28, pp. 425- 430 ,(2002) , 10.1055/S-2002-35282