Molecular basis of vascular events following spinal cord injury.

摘要: The aim of this article is to analyze the effects molecular basis vascular events following spinal cord injury and their contribution in pathogenesis. First all, we reviewed anatomy vessels. The pathophysiology injuries revealed two types pathogenic mechanisms. primary event, mechanic trauma, results a disruption neural structures into cord. It followed by secondary pathogenesis that leads progression initial lesion. We responses injury, focusing on both events. intraparenchymal hemorrhage direct consequence trauma; it has typical pattern distribution contused cord, inside gray matter and, radially extended white matter. restricted dorsal columns, adjacent rostral caudal segments. Distribution chronic lesions overlaps early hemorrhage. described mechanisms action, role, induction heme oxygenase isoenzymes 1 2. Posttraumatic inflammatory response contributes pathogenesis. analyzed cells participating response, moment appearance after decrease number, nature actions. blood–spinal barrier biphasic. exposes toxic other molecules. Endothelin mediates oxidative stress through modulation blood flow. role matrix metalloproteinases disruption, inflammation, angiogenesis are reviewed.