Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups.

作者: David L. Morris , Timothy J. Vyse , Yuanjia Tang , Yujun Sheng , Jiangshan Jane Shen

DOI: 10.1038/S41467-021-21049-Y

关键词:

摘要: … between East Asian (X-axis) and European (Y-axis) populations (… ) was found to be specifically associated with SLE in East Asians in … where H pi is the expected heterozygosity in the i th …

参考文章(86)
Chang-Fu Kuo, Matthew J. Grainge, Ana M. Valdes, Lai-Chu See, Shue-Fen Luo, Kuang-Hui Yu, Weiya Zhang, Michael Doherty, Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families JAMA Internal Medicine. ,vol. 175, pp. 1518- 1526 ,(2015) , 10.1001/JAMAINTERNMED.2015.3528
Laura S. Treml, Gianluca Carlesso, Kristen L. Hoek, Jason E. Stadanlick, Taku Kambayashi, Richard J. Bram, Michael P. Cancro, Wasif N. Khan, TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells. Journal of Immunology. ,vol. 178, pp. 7531- 7539 ,(2007) , 10.4049/JIMMUNOL.178.12.7531
Gleb Kichaev, Bogdan Pasaniuc, Leveraging Functional-Annotation Data in Trans-ethnic Fine-Mapping Studies. American Journal of Human Genetics. ,vol. 97, pp. 260- 271 ,(2015) , 10.1016/J.AJHG.2015.06.007
Sunita Kanswal, Nora Katsenelson, Windy Allman, Kadriye Uslu, Milan S. Blake, Mustafa Akkoyunlu, Suppressive Effect of Bacterial Polysaccharides on BAFF System Is Responsible for Their Poor Immunogenicity Journal of Immunology. ,vol. 186, pp. 2430- 2443 ,(2011) , 10.4049/JIMMUNOL.1002976
Sunita Kanswal, Nora Katsenelson, Angamuthu Selvapandiyan, Richard J. Bram, Mustafa Akkoyunlu, Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL. Journal of Immunology. ,vol. 181, pp. 976- 990 ,(2008) , 10.4049/JIMMUNOL.181.2.976
Hilary K Finucane, Brendan Bulik-Sullivan, Alexander Gusev, Gosia Trynka, Yakir Reshef, Po-Ru Loh, Verneri Anttila, Han Xu, Chongzhi Zang, Kyle Farh, Stephan Ripke, Felix R Day, ReproGen Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Raci Consortium, Shaun Purcell, Eli Stahl, Sara Lindstrom, John RB Perry, Yukinori Okada, Soumya Raychaudhuri, Mark J Daly, Nick Patterson, Benjamin M Neale, Alkes L Price, None, Partitioning heritability by functional annotation using genome-wide association summary statistics Nature Genetics. ,vol. 47, pp. 1228- 1235 ,(2015) , 10.1038/NG.3404
William Stohl, David M Hilbert, The discovery and development of belimumab: the anti-BLyS-lupus connection. Nature Biotechnology. ,vol. 30, pp. 69- 77 ,(2012) , 10.1038/NBT.2076
Jin-Hong Wang, Nicole Avitahl, Annaiah Cariappa, Christof Friedrich, Toru Ikeda, Anja Renold, Konstantinos Andrikopoulos, Luobin Liang, Shiv Pillai, Bruce A Morgan, Katia Georgopoulos, Aiolos regulates B cell activation and maturation to effector state Immunity. ,vol. 9, pp. 543- 553 ,(1998) , 10.1016/S1074-7613(00)80637-8
M. Nei, Analysis of Gene Diversity in Subdivided Populations Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 3321- 3323 ,(1973) , 10.1073/PNAS.70.12.3321
Antonio Fabregat, Konstantinos Sidiropoulos, Phani Garapati, Marc Gillespie, Kerstin Hausmann, Robin Haw, Bijay Jassal, Steven Jupe, Florian Korninger, Sheldon McKay, Lisa Matthews, Bruce May, Marija Milacic, Karen Rothfels, Veronica Shamovsky, Marissa Webber, Joel Weiser, Mark Williams, Guanming Wu, Lincoln Stein, Henning Hermjakob, Peter D'Eustachio, The Reactome Pathway Knowledgebase. Nucleic Acids Research. ,vol. 44, pp. 472- 477 ,(2014) , 10.1093/NAR/GKV1351