Prospect and progress of oncolytic viruses for treating peripheral nerve sheath tumors.

摘要: ABSTRACTIntroduction: Peripheral nerve sheath tumors (PNSTs) are an assorted group of neoplasms originating from the neuroectoderm and growing in peripheral nerves. Malignant transformation leads to a poor prognosis is often lethal. The current treatment PNSTs predominantly surgical, which incomplete or accompanied by significant loss function, conjunction with radiotherapy and/or chemotherapy, for benefits inconclusive. Oncolytic viruses (OVs) efficiently kill tumor cells while remaining safe normal tissues, novel antitumor therapy patients PNSTs.Areas covered: Because low efficacy treatments, new therapies needed. Preclinically, OVs have demonstrated treating perineural invasion, as well safety. We will discuss various their preclinical models, being tested treatment, including oncolytic herpes simplex virus (HSV), adenovirus (Ad), measles v...