Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

作者: Ana Jovičić , Jerome Mertens , Steven Boeynaems , Elke Bogaert , Noori Chai

DOI: 10.1038/NN.4085

关键词:

摘要: C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) produced by …

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