Efficacy of a 6-month versus 9-month Intermittent Treatment Regimen in HIV-infected Patients with Tuberculosis
作者： Soumya Swaminathan , Gopalan Narendran , Perumal Venkatesan , Sheik Iliayas , Rameshkumar Santhanakrishnan
DOI: 10.1164/RCCM.200903-0439OC
关键词:
摘要: Rationale: The outcome of fully intermittent thrice-weekly antituberculosis treatment various durations in HIV-associated tuberculosis is unclear.Objectives: To compare the efficacy an 6-month regimen (Reg6M: 2EHRZ3/4HR3 [ethambutol, 1,200 mg; isoniazid, 600 rifampicin, 450 or mg depending on body weight <60 ≥60 kg; and pyrazinamide, 1,500 for 2 mo; followed by 4 mo isoniazid rifampicin at same doses]) versus a 9-month (Reg9M: 2EHRZ3/7HR3) HIV/tuberculosis (TB).Methods: HIV-infected patients with newly diagnosed pulmonary extrapulmonary TB were randomly assigned to Reg6M (n = 167) Reg9M 160) monitored determination clinical, immunological, bacteriological parameters 36 months. Primary outcomes included favorable responses end recurrences during follow-up, whereas secondary was death. Intent-to-treat on-treatment analyses performed. All antiretroviral treatment–naiv...
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