Total Parenteral Nutrition and Complete Bowel Rest in the Management of Crohn's Disease

摘要: The role of parenteral nutrition with complete bowel rest in the management active Crohn's disease was evaluated retrospectively 100 patients who were otherwise refractory to conventional medical management. Ninety received nutrient replacement and 10 protein-sparing therapy. In 77 patients, a clinical remission achieved. Analysis subgroups revealed that rate equivalent subacute obstruction (76%), inflammatory mass (82%), uncomplicated severe (89%). However, those fistulae responded less well (63%). location intestinal involvement did not influence (73% small only 78% combined large disease). All six achieved remission. 81% remission, no corticosteroids given, or dose prior TPN maintained. serum albumin improved significantly (p than 0.001) from 3.2 +/- 0.1 3.6 g/dl total nutrition, but there significant effect on hematocrit greater 0.5). percentage still after 3 months 1 yr follow-up 75 79 58 61%, respectively, three nonfistulous groups, 46 36%, fistulous disease. Thus appears be an effective therapeutic modality primary complicated