Circulating Nucleic Acids in Health and Disease

摘要: Significant changes of the extracellular DNA and RNA concentration composition have been found in blood from patients with several pathologies compared healthy individuals, indicating their potential as disease biomarkers. Tumor-specific genome mitochondrial changes, such mutations, microsatellite instability, aberrant methylation, well mRNA microRNA detected cancer plasma serum. Several studies provided evidence for circulating nucleic acid’s involvement into development, which could be valuable development novel therapeutic approaches. In chapter, usefulness serological markers diagnosis prognosis other pathological states, including trauma, stroke, myocardial infarction, hematological disorders, complications organ transplantation, diabetes are discussed.