Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta

作者: B. G. Robinson , R. L. Emanuel , D. M. Frim , J. A. Majzoub

DOI: 10.1073/PNAS.85.14.5244

关键词:

摘要: Primary cultures of purified human cytotrophoblasts have been used to examine the expression corticotropin-releasing hormone (CRH) gene in placenta. We report here that glucocorticoids stimulate placental CRH synthesis and secretion primary This stimulation is contrast glucocorticoid suppression hypothalamus. The positive regulation by suggests rise preceding parturition could result from previously described fetal glucocorticoids. Furthermore, this increase stimulate, via adrenocorticotropic hormone, a further glucocorticoids, completing feedback loop would be terminated delivery.

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