Global trends in incidence rates of childhood liver cancers: A systematic review and meta‐analysis

摘要: Background Childhood liver cancers are relatively rare, hence inferences on incidence trends over time limited by lack of precision in most studies.Objective To conduct a systematic review and meta-analysis published contemporary childhood cancer rates worldwide.Data sources PubMed, EMBASE, CINAHL, Web Science.Study selection data extraction English-language peer-reviewed articles from 1 January 2008 to December 2019 that presented quantitative estimates for diagnostic subgroups. Review was conducted per PRISMA guidelines. Two authors independently extracted critically assessed studies.Synthesis Random effects models were used estimate pooled Heterogeneity measured using the Q I-2 statistics publication bias evaluated Egger's test.Results Eighteen studies included, all based population-based registries. Trends reported average 18 years. Overall annual percentage change (APC) 1.4 (95% confidence interval [CI] 0.5, 2.3) cancers, 2.8 CI 1.8, 3.8) hepatoblastoma -3.0 -11.0, 4.9) hepatocellular carcinoma. Sub-group analysis region indicated increasing North America/Europe/Australia (APC 1.7, 95% 0.7, 2.8) whereas corresponding stable Asia 1.4, 95%CI -0.3, 2.7). Publication not detected any these analyses. The statistic heterogeneity among included low combined moderate high carcinoma.Conclusions Incidence is commonly diagnosed subgroup hepatoblastoma. Lack knowledge etiology ability understand reasons observed trends. This highlighted need ongoing monitoring etiological studies.