Health Status in Young Adults Two Decades After Pediatric Liver Transplantation

摘要: We conducted a cross-sectional study of patients who underwent pediatric liver transplant (LT) between 1988 and 1992 to evaluate long-term health status. Survivors completed socio-demographic, medical Health-Related Quality Life (HRQOL) surveys by mail including the SF-36v2, PedsQL™4.0 Generic Core Scale, PedsQL™ Cognitive Functioning Scale PedsQL™3.0 Transplant Module. SF-36 scores were converted SF6D-based utilities risk factors for lower outcomes assessed. Eighty-five 171 had survived. Fifty-six contacted with response rate 66%. Median age at LT was 0.86 years (IQR 0.58-3.0) 64.3% biliary atresia. Mean survey 23.0 ± 4.4 years: 62% attended college, 68% lived parents 80% those over 23 employed. Patient than norms (0.75 0.12 vs. 0.82 0.18, p < 0.01) correlated unemployment (p 0.042), hospitalizations 0.005) education level 0.016). Lower Module 4.0 = 0.006, 0.009) 0.02). Pediatric recipients survive adulthood have physical HRQOL, measurable transplant-related disability utility. Transplantation is life saving; however, psychological sequelae continue affect status up two decades later.