The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma
作者： Shih-Ming Tsao , Shun-Fa Yang , Yia-Ting Li , Thomas Chang-Yao Tsao , Chia-Yi Lee
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摘要: The aim of the current study is to investigate potential associations among Long Noncoding RNA (LncRNA) H19 single nucleotide polymorphism (SNP) and epidermal growth factor receptor (EGFR) phenotypes on clinicopathological characteristics lung adenocarcinoma (LADC). Five loci LncRNA SNPs (rs217727, rs2107425, rs2839698, rs3024270, rs3741219) were genotyped by using TaqMan allelic discrimination in 223 LADC patients with wild-type EGFR phenotype 323 individuals mutations. After statistical analyses, mutation related a higher distribution frequency rs217727 SNP CT heterozygote (p = 0.030), female population demonstrated < 0.001) rs2107425 0.002). In addition, presence T allele (CT + TT) was associated tumor status (stage III or IV, p 0.037) poorer cell differentiation (poor differentiation, 0.012) compared those CC allele. Besides, prominently found subjects 0.007) patients. Our findings suggest that patients, are progressed for wild-type.
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sci-hub.st 参考文章(57)
Siddhartha Devarakonda, Daniel Morgensztern, Ramaswamy Govindan, Genomic alterations in lung adenocarcinoma The Lancet Oncology. ,vol. 16, pp. e342- e351 ,(2015) , 10.1016/S1470-2045(15)00077-7
Xiaoying Zhou, Feng Ye, Chengqiang Yin, Ya Zhuang, Ge Yue, Guoxin Zhang, The Interaction Between MiR-141 and lncRNA-H19 in Regulating Cell Proliferation and Migration in Gastric Cancer. Cellular Physiology and Biochemistry. ,vol. 36, pp. 1440- 1452 ,(2015) , 10.1159/000430309
Caicun Zhou, Lung cancer molecular epidemiology in China: recent trends. Translational lung cancer research. ,vol. 3, pp. 270- 279 ,(2014) , 10.3978/J.ISSN.2218-6751.2014.09.01
Hidefumi Sasaki, Katsuhiko Endo, Minoru Takada, Masaaki Kawahara, Naoto Kitahara, Hisaichi Tanaka, Meinoshin Okumura, Akihide Matsumura, Keiji Iuchi, Tomoya Kawaguchi, Haruhiro Yukiue, Yoshihiro Kobayashi, Motoki Yano, Yoshitaka Fujii, L858R EGFR mutation status correlated with clinico-pathological features of Japanese lung cancer Lung Cancer. ,vol. 54, pp. 103- 108 ,(2006) , 10.1016/J.LUNGCAN.2006.06.003
Patricia de Groot, Reginald F. Munden, Lung Cancer Epidemiology, Risk Factors, and Prevention Radiologic Clinics of North America. ,vol. 50, pp. 863- 876 ,(2012) , 10.1016/J.RCL.2012.06.006
Kazutoshi Isobe, Yoshinobu Hata, Naobumi Tochigi, Kyohei Kaburaki, Hiroshi Kobayashi, Takashi Makino, Hajime Otsuka, Fumitomo Sato, Fumiaki Ishida, Naoshi Kikuchi, Nao Hirota, Keita Sato, Go Sano, Keishi Sugino, Susumu Sakamoto, Yujiro Takai, Kazutoshi Shibuya, Akira Iyoda, Sakae Homma, Clinical Significance of BIM Deletion Polymorphism in Non–Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation Journal of Thoracic Oncology. ,vol. 9, pp. 483- 487 ,(2014) , 10.1097/JTO.0000000000000125
Markus D Siegelin, Alain C Borczuk, Epidermal growth factor receptor mutations in lung adenocarcinoma Laboratory Investigation. ,vol. 94, pp. 129- 137 ,(2014) , 10.1038/LABINVEST.2013.147
Gerald W. Verhaegh, Linda Verkleij, Sita H.H.M. Vermeulen, Martin den Heijer, J. Alfred Witjes, Lambertus A. Kiemeney, Polymorphisms in the H19 Gene and the Risk of Bladder Cancer European Urology. ,vol. 54, pp. 1118- 1126 ,(2008) , 10.1016/J.EURURO.2008.01.060
Haruhiko Nakamura, Hisashi Saji, A worldwide trend of increasing primary adenocarcinoma of the lung Surgery Today. ,vol. 44, pp. 1004- 1012 ,(2014) , 10.1007/S00595-013-0636-Z
J. Lortet-Tieulent, I. Soerjomataram, J. Ferlay, M. Rutherford, E. Weiderpass, F. Bray, International trends in lung cancer incidence by histological subtype: adenocarcinoma stabilizing in men but still increasing in women. Lung Cancer. ,vol. 84, pp. 13- 22 ,(2014) , 10.1016/J.LUNGCAN.2014.01.009