The rise of pneumonic plague in Madagascar: current plague outbreak breaks usual seasonal mould.

摘要: Madagascar has just emerged from the grip of an acute urban pneumonic plague outbreak, which began in August 2017, before usual season October-April and outside traditional foci northern central highlands. The World Health Organization reported a total 2417 confirmed, probable suspected cases, including 209 deaths between 1 26 November 2017. severity scope this affected those higher socioeconomic groups as well living poverty, along with factors potential for use multi-drug-resistant strains bioterrorism, highlights ongoing threat posed by ancient disease. Factors likely to have contributed transmission include human behaviour, burial practices movement people, poor planning leading overcrowding ready airborne droplets, climatic genomic subtypes. outbreak demonstrates importance identifying targeted therapies developing vaccines that can be administered planned programmes countries such where is endemic. dominance suggests we need focus more urgently on danger person-to-person transmission, problem zoonotic sources.