Nonhuman Primate Models for Human Malaria Research

摘要: Despite over 100 years of discovery supporting the value nonhuman primate models for malaria research, use these has been slow and sporadic clearly fallen short capitalizing on availability a wealth opportunities possibilities advancing knowledge in humans. This chapter provides relevant future models, recognizing that they many respects have advantages clinical samples, rodent or vitro cultures. The introduction basic understanding as widespread global disease devastating proportions, life cycle humans primates, uses research. history dozens human simian variety hosts is detailed. Basic fundamental information about species, strains, their biology infection characteristics are presented succinct organized manner, making this work reference both established scientists newcomers planning experimental using systems. With recent ongoing publications Plasmodium parasite genomes functional genomic systems approaches now at forefront science, an opportune time field. Maintenance most appropriate colonies, including Aotus, Saimiri, macaque critical, along with training experts to be intimately familiar nuances various parasite–host interactions relationships.