The contribution of childhood adversity to cortisol measures of early life stress amongst infants in rural India: Findings from the early life stress sub-study of the SPRING cluster randomised controlled trial (SPRING-ELS).

摘要: Abstract Background The majority of the world’s children live in low- and middle-income countries face multiple obstacles to optimal wellbeing. mechanisms by which adversities – social, cultural, psychological, environmental, economic get ‘under skin’ early days life become biologically embedded remain an important line enquiry. We therefore examined contribution childhood adversity through pregnancy first year hair salivary cortisol measures stress India SPRING home visits cluster RCT aims improve development. Methods assessed 22 across four domains: socioeconomic, maternal stress, family-child relationship, child summed them make a cumulative score & quintiles, subscale scores. cut 3 cm from posterior vertex took three saliva samples morning till late afternoon on each two (total six samples). analysed both for concentration using ELISA techniques. used linear regression techniques assess relationship between log diurnal slope area under curve. Results 712 hair, 752 at 12 months age. found strong positive cortisol; additional factor was associated with increases 6.1% (95% CI 2.8, 9.4, p  Discussion This is largest study young children, country setting. Whilst short-term did not appear be linked adversity, chronic exposure over several appears strongly adversity. These findings should spur further work understand specific ways becomes embedded, how this can tackled. They also lend support ongoing action tackle communities around world.