Ameliorative Effects of Testosterone Administration on Renal Redox Homeostasis in Naturally Aged Rats
作者： Karolin Yanar , Pınar Atukeren , Tamer Cebe , Ahmad Kunbaz , Tuna Ozan
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摘要: Abstract Background: Testosterone biosynthesis gradually decreases with age. Impaired redox homeostasis-related oxidative damage in cellular macromolecules has a high risk for the development of renal insufficiency. Our aim was to study effects testosterone replacement therapy on homeostasis. Methods: We investigated various biomarkers kidney. Experimental animals were separated into three groups—naturally aged rats, testosterone-administered naturally rats (single dose 25 mg/kg enanthate), and their respective young controls. Results: results showed that group shared significant similarities respect status. In kynurenine, protein carbonyl, advanced oxidation products, lipid peroxidation markers, xanthine oxidase activities significantly lower Cu-Zn superoxide dismutase ...
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Hidetaka Ota, Masahiro Akishita, Takuyu Akiyoshi, Tomoaki Kahyo, Mitsutoshi Setou, Sumito Ogawa, Katsuya Iijima, Masato Eto, Yasuyoshi Ouchi, Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1 PLoS ONE. ,vol. 7, pp. e29598- ,(2012) , 10.1371/JOURNAL.PONE.0029598
Seval Aydın, Duygu Uzun, Gülcan Güntaş Korkmaz, Mustafa Sitar, Tamer Cebe, Karolin Yanar, Ufuk Çakatay, Oxidative damage parameters in renal tissues of aged and young rats based on gender. Clinical Interventions in Aging. ,vol. 8, pp. 809- 815 ,(2013) , 10.2147/CIA.S46188
Barry R. Zirkin, Haolin Chen, Regulation of Leydig Cell Steroidogenic Function During Aging Biology of Reproduction. ,vol. 63, pp. 977- 981 ,(2000) , 10.1095/BIOLREPROD63.4.977
Willem de Ronde, Frank H de Jong, Aromatase inhibitors in men: effects and therapeutic options Reproductive Biology and Endocrinology. ,vol. 9, pp. 93- 93 ,(2011) , 10.1186/1477-7827-9-93
Fangzhen Xia, Xiao Xu, Hualing Zhai, Ying Meng, Huixin Zhang, Shichun Du, Hui Xu, Hui Wu, Yingli Lu, Castration-induced testosterone deficiency increases fasting glucose associated with hepatic and extra-hepatic insulin resistance in adult male rats. Reproductive Biology and Endocrinology. ,vol. 11, pp. 106- 106 ,(2013) , 10.1186/1477-7827-11-106
Xinhui Wang, Joseph Bonventre, Alan Parrish, The aging kidney: increased susceptibility to nephrotoxicity. International Journal of Molecular Sciences. ,vol. 15, pp. 15358- 15376 ,(2014) , 10.3390/IJMS150915358
Rebecca L. Cunningham, Meharvan Singh, Sid E. O'Bryant, James R. Hall, Robert C. Barber, Oxidative stress, testosterone, and cognition among Caucasian and Mexican-American men with and without Alzheimer's disease Journal of Alzheimer's Disease. ,vol. 40, pp. 563- 573 ,(2014) , 10.3233/JAD-131994
Thomas IS Hwang, Tien-Ling Liao, Ji-Fan Lin, Yi-Chia Lin, Shu-Yu Lee, Yen-Chun Lai, Shu-Huei Kao, None, Low-dose testosterone treatment decreases oxidative damage in TM3 Leydig cells. Asian Journal of Andrology. ,vol. 13, pp. 432- 437 ,(2011) , 10.1038/AJA.2010.159
Ufuk Cakatay, Seval Aydın, Pınar Atukeren, Karolin Yanar, Mustafa Sitar, Enis Dalo, Ezel Uslu, Increased Protein Oxidation and Loss of Protein-Bound Sialic Acid in Hepatic Tissues of D-galactose Induced Aged Rats Current Aging Science. ,vol. 6, pp. 135- 141 ,(2013) , 10.2174/18746098112059990034
Silvana A. Andric, Marija M. Janjic, Natasa J. Stojkov, Tatjana S. Kostic, Testosterone-Induced Modulation of Nitric Oxide-cGMP Signaling Pathway and Androgenesis in the Rat Leydig Cells Biology of Reproduction. ,vol. 83, pp. 434- 442 ,(2010) , 10.1095/BIOLREPROD.110.083626