作者: Ansgar Sehlinger , Michael A. R. Meier
DOI: 10.1007/12_2014_298
关键词:
摘要: Multicomponent reactions (MCRs) include more than two starting materials and are characterized by highly atom-efficient straightforward practical procedures. Some of the most important MCRs in organic chemistry isocyanide-based MCRs, namely Passerini three-component Ugi four-component reaction. These are, for example, often applied combinatorial medicinal due to their easy access diversity or creation complex structural motifs total synthesis natural products.