Biological profiles of endocrine breast cancer

摘要: Reduced or absent Wwox expression has recently been associated with tamoxifen resistance in breast cancer and also proposed as a candidate predictive marker for treatment. We aimed to investigate the correlation of outcome treatment by examining tissues from 912 randomized patients. Paraffin-embedded patient tumors were arranged on tissue microarray, protein was stained using immunohistochemistry. After microscopic examination, results analyzed Cox regression, Kaplan-Meier survival curves log-rank test. In group cases having tumor expression, there no difference recurrence-free between treated untreated patients (P=0.81). For expressing moderate strong protein, improved (P=0.001 P=0.003, respectively). The test interaction response demonstrated decreased risk recurrence (HR=0.31, 95% CI 0.10-0.98 HR=0.28, 0.08-0.97, Our indicate that high may gain more benefit tamoxifen.