Abstract P5-01-10: Tumor Optic Properties Measured Using Diffuse Optic Spectroscopy Imaging Correlate with Proliferation and Glucose Metabolism in Breast Cancer Patients

摘要: (Background) Diffuse Optic Spectroscopy Imaging (DOSI) is non-invasive imaging technology that employs near-infrared (NIR) light to quantitatively characterize the hemodynamic and metabolic properties of breast cancer tumors. (Methods) We utilized DOSI measure baseline tumor concentrations oxy-hemoglobin (ctO 2 Hb), deoxy-hemoglobin (ctHHb), total hemoglobin (ctTHb), oxygen saturation (stO ), as well water lipid content tumors from sixteen patients with primary prior neoadjuvant chemotherapy. Core-needle biopsy specimens were also collected these analyzed for Ki67, Glut-1, Fatty acid synthese (FAS), biomarkers proliferation, glucose metabolism fatty metabolism, respectively. These optic biological statistically compared each other overall therapy response. (Results) Ki67 score was positively correlated levels ctO Hb (µM) (r = 0.51, p 0.04), ctTHb 0.05), stO (%) 0.57, 0.02), negatively -0.52, 0.04). Tumors positive Glut-1 status (n=8) showed significantly higher (26.2±12.5 v.s 19.9±10.1, (41±13.3 27.5±11.7, (81.1±6.6 70.2±9.9, 0.02) lower (49±17.1 66.2±10.4, 0.03) those negative (n 8). There no correlation between FAS properties. Five (31.3%) 16 achieved pathologic complete response (pCR) after completion chemotherapy followed by surgery. pCR , likelihood expression than non-pCR (p 0.009, 0.01, 0.03, respectively). Only p-values statistical significance described. (Conclusion) Higher tumoral oxygenation concentration associated a Non-invasive measured using are potential surrogate markers proliferation metabolism. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P5-01-10.