New Pharmacological Treatment Approaches for Anxiety Disorders

作者: A. Ströhle

DOI: 10.1007/3-540-28082-0_18

关键词:

摘要: New developments in the pharmacological treatment of anxiety disorders will have distinct backgrounds: characterization pathophysiological processes including evolving techniques genomics and proteomics generate new drug targets. Drug development design substances with specific action at neurotransmitter neuropeptide receptors or affecting their reuptake metabolism. anxiolytic drugs may target receptor systems that only recently been linked to anxiety-related behavior. This includes N-methyl-D-aspartate (NMDA), S-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), cannabinoid receptors. In addition, signal transduction pathways, neurotrophic factors, gases such as nitric oxide carbon monoxide be Combining psychopharmacological psychotherapeutical interventions is a further field where benefits for could achieved. Although road arduous, improvements are expected near future.

参考文章(123)
V Vasar, E Vasar, A Aluoja, T Podar, J Bradwejn, J Shlik, Effects of citalopram treatment on behavioural, cardiovascular and neuroendocrine response to cholecystokinin tetrapeptide challenge in patients with panic disorder. Journal of Psychiatry & Neuroscience. ,vol. 22, pp. 332- 340 ,(1997)
Elizabeth P. Bauer, Joseph E. LeDoux, Karim Nader, Fear conditioning and LTP in the lateral amygdala are sensitive to the same stimulus contingencies Nature Neuroscience. ,vol. 4, pp. 687- 688 ,(2001) , 10.1038/89465
Chih-Hung Lin, Shiu-Hwa Yeh, Tzeng-Horng Leu, Wen-Chang Chang, Shan-Tair Wang, Po-Wu Gean, Identification of Calcineurin as a Key Signal in the Extinction of Fear Memory The Journal of Neuroscience. ,vol. 23, pp. 1574- 1579 ,(2003) , 10.1523/JNEUROSCI.23-05-01574.2003
Todd E. Thiele, Donald J. Marsh, Linda Ste. Marie, Ilene L. Bernstein, Richard D. Palmiter, Ethanol consumption and resistance are inversely related to neuropeptide Y levels Nature. ,vol. 396, pp. 366- 369 ,(1998) , 10.1038/24614
Toshimitsu Kishimoto, Jelena Radulovic, Marko Radulovic, Chijen R. Lin, Christina Schrick, Farideh Hooshmand, Ola Hermanson, Michael G. Rosenfeld, Joachim Spiess, Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2 Nature Genetics. ,vol. 24, pp. 415- 419 ,(2000) , 10.1038/74271
Peter Timpl, Rainer Spanagel, Inge Sillaber, Adelheid Kresse, Johannes MHM Reul, Günter K Stalla, Veronique Blanquet, Thomas Steckler, Florian Holsboer, Wolfgang Wurst, None, Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1 Nature Genetics. ,vol. 19, pp. 162- 166 ,(1998) , 10.1038/520
R Landgraf, R Gerstberger, A Montkowski, JC Probst, CT Wotjak, F Holsboer, M Engelmann, V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats The Journal of Neuroscience. ,vol. 15, pp. 4250- 4258 ,(1995) , 10.1523/JNEUROSCI.15-06-04250.1995
Tracy L. Bale, Angelo Contarino, George W. Smith, Raymond Chan, Lisa H. Gold, Paul E. Sawchenko, George F. Koob, Wylie W. Vale, Kuo-Fen Lee, Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nature Genetics. ,vol. 24, pp. 410- 414 ,(2000) , 10.1038/74263