Persistent inhibition of human natural killer cell function by ziram and pentachlorophenol.

摘要: Ziram is a currently used agricultural fungicide. It also as an additive in the production of latex gloves. Because these uses, there potential for human exposure to this compound. Pentachlorophenol (PCP) has been insecticide, fungicide, disinfectant, and ingredient antifouling paints. Currently, it wood preservative power-line poles fence posts. Measurable levels PCP have detected blood urine. In previous studies we demonstrated that both compounds could cause very significant inhibition tumor-killing function natural killer (NK) cells. NK lymphocytes play central role immune defense against viral infection formation primary tumors. So interference with their increase risk tumor development. present study examined effects ziram or brief duration (1 h) on ability cells destroy were exposed either (5–0.5 μM) (10–5 1 h followed by 0 h, 24 48 6 days compound-free media then tested lyse well bind A 1-h little 2.5 μM decreased target cells, which persisted up following exposure. The loss lytic from was accompanied comparable capacity Exposure 10 caused progressive (greater than 80%) within contrast ziram, no accompanying binding function. © 2005 Wiley Periodicals, Inc. Environ Toxicol 20: 418–424, 2005.