Molecular modelling of disease-causing single-nucleotide polymorphisms in collagen.
作者： J. V. Milchevsky , V. E. Ramensky , N. G. Esipova , V. G. Tumanyan , B. S. Zorov
DOI: 10.1080/10629360108033246
关键词:
摘要: Abstract The purpose of the work was to investigate at molecular structural and energy levels consequence amino acid substitutions in collagen that cause systemic diseases. data have been systematized on defects human III, patterns single-nucleotide polymorphisms collected. Then mechanics calculations were performed for native mutant molecule fragments. observed components alterations accompany particular used propose an interpretation negative consequences terms stability hydration macromolecule.
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