Prostaglandin production by methylcholanthrene-transformed mouse BALB/3T3: effect of oxidative phosphorylation inhibitors.

摘要: Abstract Oligomycin, antimycin, and 2,4-dinitrophenol, compounds that are known to inhibit oxidative phosphorylation by different mechanisms, the production of prostaglandins serum-stimulated MC5-5 cells. The prostaglandin is stimulated thrombin bradykinin inhibited 2,4-dinitrophenol. Prostaglandin synthesis cells from exogenously-supplied arachidonic acid, however, not affected Antimycin 2,4-dinitrophenol also release acid cellular lipids, suggesting it expression phospholipase activity, a prerequisite for cells, dependent on phosphorylation.