Sequence-Specifically Addressable Hairpin DNA−Single-Walled Carbon Nanotube Complexes for Nanoconstruction

摘要: Single-walled carbon nanotubes (SWCNTs) are attractive building blocks for molecular electronics and novel materials. Generating functional architectures with SWCNTs requires methodologies dispersing, purifying, binding these highly insoluble quasi one-dimensional molecules. We have previously shown that unstructured DNA strands bind to so tightly it is difficult address them complementary strands. Here we show hairpin oligonucleotides give SWCNT suspensions more concentrated than those obtainable optimized sequences. Further, hairpin-forming (6,5)-SWCNTs form complexes addressable complementary, triplex-forming oligonucleotides. As proof of principle, DNA−SWCNT can be bound sequence-specifically featuring fluorophores or quantum dots. The new method brings exquisite purity into the realm DNA-based nanostructuring.