T-Cell Therapies for Epstein-Barr Virus-Associated Lymphomas

摘要: Epstein-Barr virus (EBV)-associated lymphomas represent a broad spectrum of diseases and can be characterized by their pattern viral latency. These pathologies display the importance healthy T cell–mediated control EBV-infected B cells. Burkitt's lymphoma is least immunogenic has type I latency pattern. Hodgkin's variety non-Hodgkin's exhibit antigens II Posttransplant lymphoproliferative disease in solid organ hematopoietic stem cell transplant setting as well arising primary immunodeficiency patients are tumors with III This last group expresses all 9 latent proteins most immunogenic. T-cell approaches including donor lymphocyte infusions adoptive transfer EBV-specific cytotoxic lymphocytes used to treat these diseases. The authors describe biology EBV-associated review methodology outcomes existing cell–based therapies strateg...