The Role of Cell Death and Related Phenomena During Formation of the Optic Pathway

摘要: In most species of birds and mammals, large numbers cells normally become necrotic are resorbed within the primitive retinal rudiment. Since degenerating may fragment upon their demise, absolute difficult to quantify. However, if one assumes that individual “sites” debris represent breakdown products single then counts total viable rat retina at a particular stage early development (day 12.5 when rate cell death is maximum), it apparent nearly 30% this count consist population (Silver Hughes, 1973). Von Szily (1912) first recognized massive phenomenon suggested dying might be arranged in rows or columns. Thus, he postulated removal would leave pathways chemical “channels” which could exert chemotactic influence on outgrowing ganglion nerve fibers (Von Szily, 1912).