Dendritic Cell-Based Vaccines

摘要: Dendritic cells (DCs) acquire, process, and present antigens to T-cells, provide the stimulatory signals cytokines required induce T-cells proliferate differentiate into effector cells. For this reason, infusion of in vitro-generated antigen-loaded DCs has been investigated as a vaccination strategy elicit T-cell-mediated responses, particularly context cancer where DC function vivo is often blunted or subverted by factors released tumor. While studies mice have repeatedly shown that DC-based vaccines can delay prevent tumor progression, human clinical trials disappointing comparison, offering only marginal benefit for patients. There therefore still need improve capacity injected improving antigen-loading strategies, refining differentiation maturation protocols, considering how encourage interactions with innate may help sustain cytokine production vivo. Perhaps most significant hurdles effective immunotherapy are inhibitory “checkpoints” commonly hijacked tumors suppress T-cell function. We argue promising avenue be combinatorial approaches, used responses desired properties immune protection, while checkpoint blockade those face tumor-induced suppressive activities.