The Cutaneous Microbiota as a Determinant of Skin Barrier Function: Molecular Interactions and Therapeutic Opportunities

摘要: As the largest organ of human body, skin provides first barrier against environmental insults, including invading pathogens. Many studies have defined commensal bacteria; more recent metagenomic extended characterization microbiota to resident fungi and viruses. The is dominated by members Actinobacteria, Firmicutes, Proteobacteria, Bacteroidetes, Malassezia spp., bacteriophages Defining both healthy affected insight into influence cutaneous on immune responses disease states. Crosstalk between innate system facilitates proper response healing. Commensal bacteria appear protect from pathogens directly releasing antibacterial products indirectly stimulating responses. Skin pathologies such as atopic dermatitis, rosacea, psoriasis acne are characterized disruptions certain pathways imbalances microbiota. Additionally, susceptibility infection appears be influenced microbial community present skin, while resultant alters Understanding role in disorders may lead novel therapies that aim restore balance microbes.